OneKey has built a strong reputation with open-source software and broad chain support. Ledger remains the benchmark that challengers are measured against.
OneKey uses a secure element and publishes open-source firmware. Ledger uses a certified secure element with a long track record of independent audits. Both are solid, but Ledger has more history.
OneKey's app is clean and supports many chains, but Ledger Live plus the wider integration with MetaMask, Phantom and other wallets gives Ledger a deeper ecosystem.
Both offer multiple devices at different price points. OneKey is often slightly cheaper, while Ledger has more accessories and third-party support.
OneKey is a genuinely good wallet and a fine alternative. Ledger still wins on ecosystem depth and long-term trust for most users.